Aim: To present an overview and the specificities of the biology and epidemiology, pathogenesis and diagnostics, public health aspects, vaccination and control of brucellosis as a global zoonosis.
Methods: Of the various methods to control brucellosis in animals such as vaccination, hygiene, and test and slaughter of infected animals, widespread vaccination is the most rapid, efficient and effective procedure.
Results: Despite much progress in the control and sometimes eradication of brucellosis in cattle in many countries, the situation with the disease in small ruminants is proving to be much more difficult. Political and socioeconomic problems are deterrents to success. It is a veterinary responsibility to accept the challenge to control animal brucellosis, which will then control the disease in humans. The success of the control effects will be primarily measured by a decrease in human cases.
Conclusion: Effective control of brucellosis requires a long-term commitment from many governmental agencies. Assistance from international animal and human health organizations in resources and expertise is necessary in many developing countries. There are no easy solutions. Research on alternative strategies in vaccines and their usage, diagnostic tests, and treatments should be encouraged.
Martins H, Garin-Bastuji B, Lima F, Flor L, Pina Fonseca A, Boinas F. Martins H, et al. Prev Vet Med. 2009 Jul 1;90(1-2):80-9. doi: 10.1016/j.prevetmed.2009.04.002. Epub 2009 May 12. Prev Vet Med. 2009. PMID: 19439382
Benkirane A. Benkirane A. Rev Sci Tech. 2001 Dec;20(3):757-67. Rev Sci Tech. 2001. PMID: 11732418 Review. French.
Zhang N, Huang D, Wu W, Liu J, Liang F, Zhou B, Guan P. Zhang N, et al. Prev Vet Med. 2018 Nov 15;160:105-115. doi: 10.1016/j.prevetmed.2018.10.002. Epub 2018 Oct 9. Prev Vet Med. 2018. PMID: 30388992 Review.
Olsen S, Tatum F. Olsen S, et al. Vet Clin North Am Food Anim Pract. 2010 Mar;26(1):15-27, table of contents. doi: 10.1016/j.cvfa.2009.10.006. Vet Clin North Am Food Anim Pract. 2010. PMID: 20117540
Lopetegui P. Lopetegui P. Dev Biol (Basel). 2004;119:473-9. Dev Biol (Basel). 2004. PMID: 15742662 Review.
Djibril ASD, Bothon FTD, Boko KC, Koutinhouin BG, Farougou S. Djibril ASD, et al. Vet World. 2024 Feb;17(2):434-447. doi: 10.14202/vetworld.2024.434-447. Epub 2024 Feb 23. Vet World. 2024. PMID: 38595653 Free PMC article.
Ma R, Li C, Gao A, Jiang N, Feng X, Li J, Hu W. Ma R, et al. Infect Dis Poverty. 2024 Jan 8;13(1):3. doi: 10.1186/s40249-023-01170-4. Infect Dis Poverty. 2024. PMID: 38191468 Free PMC article. Review.
Wang H, Clapp B, Hoffman C, Yang X, Pascual DW. Wang H, et al. J Immunol. 2023 May 15;210(10):1576-1588. doi: 10.4049/jimmunol.2300071. J Immunol. 2023. PMID: 37036290 Free PMC article.
Shevtsov A, Cloeckaert A, Berdimuratova K, Shevtsova E, Shustov AV, Amirgazin A, Karibayev T, Kamalova D, Zygmunt MS, Ramanculov Y, Vergnaud G. Shevtsov A, et al. Front Microbiol. 2023 Mar 22;14:1106994. doi: 10.3389/fmicb.2023.1106994. eCollection 2023. Front Microbiol. 2023. PMID: 37032899 Free PMC article.
Khoshnood S, Pakzad R, Koupaei M, Shirani M, Araghi A, Irani GM, Moradi M, Pakzad I, Sadeghifard N, Heidary M. Khoshnood S, et al. Front Vet Sci. 2022 Dec 22;9:976215. doi: 10.3389/fvets.2022.976215. eCollection 2022. Front Vet Sci. 2022. PMID: 36619963 Free PMC article.